https://novapublishers.com Publisher of Books and Journals in Medicine and Health, Science and Technology and Social Sciences Thu, 02 Feb 2023 14:40:20 +0000 en-US hourly 1 https://wordpress.org/?v=6.1.1 https://novapublishers.com/wp-content/uploads/2018/08/cropped-nova-favicon-32x32.jpg https://novapublishers.com 32 32 https://novapublishers.com/shop/ectopic-pregnancy-endless-challenges/ Sun, 25 Dec 2022 14:00:22 +0000 https://novapublishers.com/?post_type=product&p=141940 Elisa Picardo, Marco Mitidieri and Saverio Danese Gynecology and Obstetrics, City of Health and Science of Turin, Sant'Anna Hospital, Italy Series: Obstetrics and Gynecology Advances BISAC: MED033000 DOI: 10.52305/MWOY3295 An ectopic pregnancy occurs when a fertilized egg grows outside of the uterus. Almost all ectopic pregnancies—more than 90%—occur in a fallopian tube. As the pregnancy progresses, it can cause the tube to burst (rupture). A rupture can cause major internal bleeding, leading to a life-threatening emergency. Over the years, treatment options have changed significantly, and mortality has reduced up to 2/1,000 (from 12.3% in 1920). This topic is always very important for the gynecologist community. This text, whose contributions have been promoted by Acto Piemonte Onlus and Ricerca per la Donna (RiDO), aims to provide a practical guide for future research on women’s health. **Order the printed version and SAVE 50% on the e-book with Print+eBook. Price indicated includes shipping**]]> https://novapublishers.com/shop/endometrial-cancer-current-epidemiology-detection-and-management-second-edition/ Fri, 28 Oct 2022 15:34:02 +0000 https://novapublishers.com/?post_type=product&p=127471 Samir A. Farghaly, M.D., PhD - Professor, New York Presbyterian Hospital, Cornell University Medical Center, Cornell University, New York, NY, USA Series: Obstetrics and Gynecology Advances BISAC: MED033000; MED062000 DOI: 10.52305/XDFN1391 The purpose of this book is to provide a broad background of several aspects of basic sciences, clinical, therapeutic aspects, and management of endometrial cancer. It provides state-of-the-art information on the molecular genetics, biology, and clinical aspects of premalignant lesions of the endometrium and endometrial cancer. Also, the book chapters provide better understanding of the molecular and cellular events that underlie endometrial cancer. The descriptive and analytical epidemiology of endometrial cancer are presented in Chapter 1. The pathology and molecular diagnosis of endometrial cancer are discussed in Chapter 2. The molecular pathology of endometrial cancer is detailed in Chapter 3. The hereditary aspect of endometrial cancer is highlighted in Chapter 4. Precancerous lesions of the endometrium are reviewed in detail in Chapter 5. Endometrial biomarkers are detailed in Chapter 6. Lymphatic mapping of endometrial cancer is discussed in Chapter 7. Sentinel lymph nodes in endometrial cancer are highlighted in Chapter 8. The current strategies and approaches to treat patients with endometrial cancer are detailed in Chapter 9. Surgical techniques for endometrial cancer are reviewed in Chapter 10. The current treatment of advanced endometrial cancer is discussed in Chapter 11. Adjuvant medical therapeutic modalities are reviewed in Chapter 12. Targeted therapies for advanced endometrial cancer are presented in Chapter 13. The role of ErbB targeted therapy in treating endometrial cancer is discussed in Chapter 14. Finally, the quality of life of women with endometrial cancer is reviewed in Chapter 15. This book is intended for all clinicians and basic medical scientists caring for women with endometrial cancer, including attending surgeons and physicians, clinical fellows, and residents in the disciplines of gynecologic oncology, medical oncology, and surgical oncology, as well as PhD students and post-doctoral fellows in the basic medical sciences.]]> https://novapublishers.com/shop/hormonal-treatments-in-gynaecology/ Sun, 17 Apr 2022 18:31:11 +0000 https://novapublishers.com/?post_type=product&p=115195 María Teresa Gómez García, PhD (Editor) - Obstetrics and Gynecology Department, University and Hospital Complex of Albacete, Spain; Medical Science Department, School of Medicine of Albacete, Spain Series: Obstetrics and Gynecology Advances BISAC: MED033000 DOI: https://doi.org/10.52305/JJLT9276 Hormonal Treatments in Gynaecology provides a detailed review of all the hormones used in gynaecology. It contains overall information and specific information of each hormone which could be very interesting in real practice. **Order both the printed version and the e-book together and SAVE!**]]> https://novapublishers.com/shop/a-closer-look-at-pregnancy-and-childbirth/ Fri, 28 Jan 2022 17:01:11 +0000 https://novapublishers.com/?post_type=product&p=111207 Louise J. Salgado (Editor) Series: Obstetrics and Gynecology Advances BISAC: MED033000 This volume includes nine chapters that detail treatment options for health problems associated with pregnancy and childbirth. Chapter One gives an overview of the various technologies and techniques that can be used for prenatal diagnosis. Chapter Two collects the latest evidence on treatment for tubal ectopic pregnancy and highlights the impact that drugs and surgical techniques used for this purpose may have. Chapter Three discusses the problem of human childbirth and the rise of caesarean sections from the viewpoint of evolutionary anthropology. Chapter Four collects the latest evidence on treatment for non-tubal ectopic pregnancy. Chapter Five proposes a risk score model for venous thromboembolism prophylaxis for caesarean sections that balances clinical risks and cost-effectiveness. Chapter Six establishes a differential protocol for placenta praevia based on a model of risk factors to enable food outcomes in caesarean section. Chapter Seven provides a detailed analysis of the various therapeutic options available for ectopic tubal and non-tubal pregnancy, and their indications, contraindications and special considerations during the COVID-19 pandemic and patients affected with this disease. Chapter Eight addresses the impact of ectopic pregnancy and the effects of treatments on patients’ fertility. Finally, Chapter Nine addresses the course of ectopic pregnancy from diagnosis to treatment.]]> https://novapublishers.com/shop/hyaluronic-acid-role-in-pregnancy-and-novel-applications-in-the-gestational-period/ Mon, 21 Jun 2021 15:38:14 +0000 https://novapublishers.com/?post_type=product&p=99208 Series: Obstetrics and Gynecology Advances BISAC: MED033000 This book offers a valuable clinical resource for health professionals and researchers. It gives an overview about the pivotal role played by High Molecular Hyaluronic Acid (HMW-HA) during pregnancy and its applications in the gestational period. Hyaluronic acid is a critical component of the extracellular matrix (ECM) and one of the most interesting, versatile and useful natural molecules in almost all areas of biology. As widely reported, HA has a pivotal role in several phases of pregnancy, from fertilization to labour and it displays several regulatory activities and functional properties based on its different molecular weight. While low molecular weight hyaluronic acid (LMW-HA) is widely used in gynaecology for menopause-related symptoms or in association with physical treatments (e.g., radiation therapy) to counteract the onset of adverse events, HMW-HA has been poorly evaluated as clinical treatment. Its physiological presence in the extracellular matrix of all the main organs and tissues involved in pregnancy (uterus, cervix, placenta, decidua, chorion, amnios, ovarium etc..) suggests the importance of this molecule for a successful gestation. Several papers, in particular, shed light on its importance for blastocyst adhesion and implantation, for an efficient immune tolerance and for the correct development of haemo-lymphatic system. It has been demonstrated that HMW-HA has regulatory activity on the PGRMC1 expression, a specific progesterone receptor expressed in maternal and foetal-maternal interface tissues, involved in uterine quiescence. On these premises, the administration of HMW-HA may represent an interesting treatment opportunity for the prevention of recurrent miscarriage and pre-term birth (PTB) in patients with risk factors. The high safety profile of HMW-HA further supports its administration in pregnancy. All these interesting topics will be discussed and deepened in this book, giving the opportunity to explore in detail every aspect of this effective and attractive molecule, thus helping physicians to assess the state of connective tissues in pregnancy and to evaluate the risk for the onset of gestational complications.]]> https://novapublishers.com/shop/intracytoplasmic-sperm-injection-icsi-clinical-considerations-outcomes-and-potential-health-effects/ Wed, 02 Jun 2021 14:00:03 +0000 https://novapublishers.com/?post_type=product&p=97997 Murid Javed (Editor) - Laboratory Director at OriginElle Fertility Clinic and Women's Health Centre, Ottawa and Montreal, Canada Series: Human Reproductive System - Anatomy, Roles and Disorders BISAC: MED082000 Target Audience: This book is very useful for medical students, andrologists, embryologists, nurses or anyone else interested in learning basic or advanced knowledge of assisted reproductive technology, especially ICSI. Description: This book provides comprehensive information on Intracytoplasmic Sperm Injection (ICSI), its clinical considerations, outcomes and potential health effects. Male and female infertility is increasing all over the world. The basic techniques of assisted reproduction like ovulation control and intrauterine insemination are ineffective if the sperm quality or number is inadequate. The advanced fertilization techniques are in-vitro fertilization (IVF) and ICSI. In 15% cases of infertility, IVF results in total failed fertilization; therefore, ICSI must be used. Some clinics exclusively use ICSI for all infertility patients due to its reliability of fertilization outcome or to avoid total fertilization failure. ICSI was first used in humans in 1992. Since then, tremendous advances have been made in assisted reproductive technology. ICSI has enabled even those men who have rare sperm in their testes to father a biological child. If no sperm are observed in the ejaculate, in almost all cases, they can be recovered from the testicles. Such retrieved sperm can only be used by ICSI. Therefore, its understanding is essential not only for medical staff but also for patients suffering from infertility. This book is highly recommended for patients suffering from infertility or currently undergoing infertility treatment. It explains the factors affecting ICSI success rate. In ICSI, the embryologist picks a sperm for injection to fertilize oocytes whereas in intrauterine insemination and IVF, one sperm penetrates naturally. This manual selection of sperm has raised concerns especially in those patients suffering from severe male factor infertility. The nature of sperm defects varies and could be congenital, acquired or genetic. Children born through ICSI are, therefore, considered at higher risk of carrying the defect. Many investigations have been carried out to compare incidence of the defects between children conceived naturally and conceived through ICSI. Additional technologies have been developed to ensure the birth of a normal child. These include pre-implantation genetic testing and non-invasive prenatal testing. This book addresses these concerns and explains the health effects on children born through ICSI. The authors of the chapters of this book are highly experienced and from different parts of the world. Many of them are directing very busy ART laboratories at leading infertility clinics in the United States of America, Canada and the Middle East.]]> https://novapublishers.com/shop/fertility-preservation-in-gynecological-cancer-current-management-and-novel-insights/ Fri, 22 Jan 2021 17:09:30 +0000 https://novapublishers.com/?post_type=product&p=90684 Obstetrics and Gynecology Advances Cancer Etiology, Diagnosis and Treatments BISAC: MED033000, MED062000 This book was written for the complex scenario of fertility-sparing management in gynecological cancer. In reproductive age women, appropriate counseling is mandatory in any cancer diagnosis, including discussing the long-term consequences of the different treatment options on fertility and the possibility of fertility preservation. However, women affected by gynecological cancer must consider that treatment options include hysterectomy and bilateral oophorectomy in most cases. Therefore, in gynecological cancer, the standard treatment often consists of an inevitable loss of fertility. The direct consequence is that fertility preservation management does not always result in the optimal treatment of the disease, which increases the risk of worsening oncologic outcomes. This book discusses all the elements involved in managing these patients to provide a complete and detailed overview of fertility preservation management options in young women affected by gynecological cancers. Specifically, this book discusses the role of genetic assessment and counseling, the effect of anticancer treatments for gynecological cancer on fertility, classic fertility preservation techniques adapted to gynecological cancer, detailed and specific fertility preservation management for cervical, ovarian, and endometrial cancer, and the role of a multidisciplinary approach in these patients.]]> https://novapublishers.com/shop/ovarian-reserve-current-trends-and-applications/ Mon, 02 Nov 2020 16:04:17 +0000 https://novapublishers.com/?post_type=product&p=87930 Obstetrics and Gynecology Advances BISAC: MED033000 DOI: 10.52305/XAWD3565 This is the first book that provides a comprehensive and in-depth account of the current state of knowledge on the ovarian reserve and its clinical applications in gynaecology and reproductive medicine. “Ovarian reserve” is a term commonly used to reflect the total number of remaining primordial follicles, which determines a woman’s fertility potential. Since its emergence in the late 1980s during the early days of assisted reproduction technology, the concept of ovarian reserve has continued to gain importance in clinical practice and research, as reflected by the exponentially growing number of publications on the topic. A wide range of ovarian reserve markers have been introduced over the years, starting with serum follicle stimulating hormone level in 1988 and most recently anti-Müllerian hormone in 2002. This book starts with a detailed background on the physiology of the ovarian reserve including early ovarian development, follicular dynamics, and the natural history of primordial follicles. This is followed by a comprehensive account of the various biochemical, sonographic, and dynamic markers and their current applications. A special chapter is devoted to anti-Müllerian hormone, which is the most extensively researched and widely used ovarian reserve marker. The role of anti-Müllerian hormone and its clinical utility in polycystic ovarian syndrome is presented in a separate chapter. The book then explores the clinical applications of ovarian reserve testing in various reproductive disorders, including early ovarian aging, diminished ovarian reserve (pathological and iatrogenic), poor ovarian response during assisted reproduction technology, and premature ovarian insufficiency.]]> https://novapublishers.com/shop/from-pap-smears-to-hpv-vaccines-evolution-of-the-cervical-cancer-prevention-industry/ Mon, 28 Sep 2020 18:22:04 +0000 https://novapublishers.com/?post_type=product&p=86176 Sin Hang Lee, MD (Author) - Director, Milford Molecular Diagnostics Laboratory, Milford, CT, US Series: Obstetrics and Gynecology Advances; Women's Issues DOI: 10.52305/KGUY3866 This book titled “From Pap Smear to HPV Vaccine − the Cervical Cancer Prevention Industry” by Dr. Sin Hang Lee provides a comprehensive analysis of how the HPV industry has invaded and eroded the women’s health care system in the field of cervical cancer prevention. The analysis based on currently available science and public records provides the readers interested in cervical cytopathology, HPV molecular diagnostics and HPV vaccination with a clear understanding of issues and solutions to cervical cancer prevention. Pap smear screening in the United States was first implemented as an annual test in the late 1940s. Its widespread use for early detection of precancerous cells destined to proceed to invasive carcinoma for timely ablative treatment markedly reduced the morbidity and mortality rates of cervical cancer. No one should die of cervical cancer if every woman continued receiving proper annual Pap smear screening carried out by a team of cytology technologist, pathologist and gynecologist. However, this teamwork broke down when cytology samples were sent to geographically distant centralized commercial laboratories for screening. Under such business atmosphere, cytology screeners, pathologists and gynecologists hardly speak to one another to discuss any potential diagnostic problems. Overwhelming numbers of unnecessary colposcopic biopsies have been performed on essentially healthy women when “false positive” cytology reports are sent to their gynecologists. However, it is the false-negative results which draw public attention while stories about Pap smear litigation cases are circulated around social media sites when follow-up tests unexpectedly reveal an invasive cancer during the patient’s annual screening. Further chaos was created after human papillomavirus (HPV) infections were discovered by Dr. Harald zur Hausen to be one of the most important risk factors for developing cervical cancer. A handful of opportunists successfully persuaded the Food and Drug Administration to regulate their HPV assays as cancer tests and anti-HPV vaccines as cancer vaccines so that they can market these products by tapping into the public’s fear of cancer. Commercial HPV tests detect many reversible cytopathology changes with high viral loads per cell, but are not sensitive enough to detect high-grade precancerous cells with low viral loads per cell. Without performing DNA sequencing, none of these test kits can provide an accurate genotyping for follow-up of persistent HPV infections, a true cancer risk. This book points out there is no factual evidence that HPV vaccination has prevented a single case of cervical cancer. Using reversible precancerous histologic changes as surrogate endpoints in clinical trials to support the claim of efficacy of HPV vaccination in prevention of cervical cancer is flawed. Since the HPV vaccine Gardasil relies on using residual HPV L1 gene DNA fragments bound to aluminum salt as the toll-like receptor 9 agonist to boost innate immune response, high levels of pro-inflammatory cytokines are generated in the vaccinees. These pro-inflammatory cytokines may cause serious adverse events in genetically and physically predisposed individuals. Women consumers are advised to read this book before choosing the modalities for cervical cancer prevention to protect their own health and lives as well as those of their loved ones.]]> https://novapublishers.com/shop/preeclampsia-diagnosis-treatment-and-management/ Tue, 22 Sep 2020 13:37:33 +0000 https://novapublishers.com/?post_type=product&p=84332 Professor Michele Fichera, MD (Editor) - Obstetrics and Gynecology Unit, Department of General Surgery and Medical Surgical Specialties, University of Catania, Sicily Series: Obstetrics and Gynecology Advances BISAC: MED033000 Preeclampsia is becoming an increasingly common diagnosis in the developed world and remains a high cause of maternal and fetal morbidity and mortality in the developing world. It is a multisystem progressive disorder of pregnancy characterized by the new onset of hypertension and proteinuria of ≥300 mg/day or of hypertension and significant end-organ dysfunction with or without proteinuria. It also presents with a variety of organ failures, including malfunction of kidneys, liver and lungs. It is estimated that about 5-7% of pregnancies are complicated by preeclampsia. This disorder always resolves after delivery. In about 80% of cases, pregnancy ends with good maternal and fetal outcomes. However, these pregnancies are still at increased risk for maternal and/or fetal mortality or serious morbidity. The remaining 20% of cases are at risk for preterm delivery and small gestational age infant. As regards the long-term consequences, women with preeclampsia are at high risk for cardiovascular, renal, and chronic hypertensive diseases. The exact pathophysiology of preeclampsia is poorly understood and, consequently, there are no well-established methods of primary prevention or of cost-effective screening. Childbirth is the only known cure; however, the decision between delivery and expectant management depends on several factors, such as fetal gestational age, maternal and fetal status at time of initial evaluation, presence of labor or rupture of fetal membranes, and level of available neonatal and maternal services. The aim of this book is to provide an overview of the latest developments about the physiopathology, diagnosis, and treatment of pre-eclampsia. Addressed to gynecologists, obstetricians, researchers and students, this text aims to become a reference for all operators who are interested in pregnancy complications and in the management and treatment of this specific disorder which is increasingly common in the population.]]> https://novapublishers.com/shop/preterm-birth-prevalence-risk-factors-and-management/ Thu, 25 Jun 2020 14:18:07 +0000 https://novapublishers.com/?post_type=product&p=75479 Agnita Malik and Adaja Baarda (Editors) Series: Women's Issues BISAC: MED033000 Preterm birth is defined by WHO as birth before the 36 weeks and 6 days of gestation or before 259 days, counting from the first day of the last menstrual period. Preterm Birth: Prevalence, Risk Factors and Management presents an overview of the epidemiologic characteristics of women who deliver their neonates prematurely, in order to understand the depth of this major obstetrical problem. Paternal risk factors, including paternal anthropometric and genetic characteristics and life-style habits, are addressed in conjunction with fetal characteristics which may be responsible for increasing the risk of preterm birth. The authors discuss three important omega-3 fatty acids for the prevention of osteopenia of the preterm newborn: alpha-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid. The concluding study explores the mechanisms that link periodontitis with adverse pregnancy outcomes and presents a comprehensive critical review of the current scientific stand regarding this relationship.]]> https://novapublishers.com/shop/endometriosis-from-diagnosis-to-treatment/ Fri, 03 Apr 2020 16:35:57 +0000 https://novapublishers.com/?post_type=product&p=70869 Simone Ferrero, MD, PhD (Editor) Associate Professor of Obstetrics and Gynaecology, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Italy Unit of Obstetrics and Gynaecology, IRCCS AOU San Martino – IST, Genova, Italy Fabio Barra (Editor) Academic Unit of Obstetrics and Gynecology University of Genoa Genoa, Italy Endometriosis is a chronic benign estrogen-dependent disease which is characterized by the presence of endometriotic glands and stroma outside the uterine cavity. It affects women during reproductive age, but it may also be diagnosed in menopausal women. Endometriosis can be asymptomatic; but most frequently it can be responsible for pain symptoms and/or infertility, severely impacting women’ quality of life. Overall, clinical presentation depends on the location of endometriotic lesions: intestinal symptoms can occur in case of bowel nodules whereas urinary symptoms can occur in case of urinary tract endometriosis. At the moment, the exact prevalence of endometriosis is unknown because its definitive diagnosis requires surgery and histological evaluation. It has been estimated that this benign chronic disease affects at least 3.6% of reproductive age women; however, its prevalence could significantly increase considering women suffering from dysmenorrhea, chronic pelvic pain and/or infertility. The etiology of endometriosis is unclear: various factors, such as multiple abnormalities of the immune system, genetic factors and environmental factors may influence women’ susceptibility to develop this chronic disease. Although the gold standard for the diagnosis of endometriosis is the pathological evaluation of surgical biopsies or specimens, today transvaginal ultrasonography is largely employed to reliably identify the presence of deep infiltrating endometriosis or ovarian endometriomas. The aim of the surgery for endometriosis is to restore the normal anatomy by removing endometriotic lesions and by performing adequate removal of abdominal adhesions. However, surgery, in case of deep infiltrating implants, can be rather challenging for gynecologists due to the complexity of pelvic adhesions involving several structures and it may be characterized by rare but not negligible urological, intestinal, neurological and vascular complications. Furthermore, pain may recur after conservative surgery for endometriosis. Although surgery is obviously required in cases of ureteral stenosis, bowel occlusion or ovarian cysts with doubtful characteristics of malignancy, medical therapy, and, particularly, hormonal therapies, are the initial therapeutic approach today for most patients with endometriosis-related pain. Long-term medical therapy for endometriosis aims to minimize the production and action of estradiol, inhibiting the production of cyclic hormones from the ovaries. Numerous medical options (such as estroprogestins, progestins, gonadotropin- releasing hormones analogs and antagonists) are available for treating women with endometriosis: the choice of the most suitable compound is based on several factors, such as intensity of pain, age, desire to conceive, costs, route of administration and impact of the endometriosis on work capacity, sexual function and quality of life of each women. Currently, research is focused on finding new innovative targets to treat this benign chronic disease; in fact, it is well known that development, maintenance and progression of endometriosis depend on a variety of aberrant mechanisms including cell proliferation, immune function, apoptosis, invasion capacity and angiogenesis. The aim of this book is to give an accurate overview on pathogenesis, diagnosis and therapy of endometriosis. (Imprint: Nova Medicine and Health)     Series: Obstetrics and Gynecology Advances BISAC: MED033000]]>