Dominika Bąk, David Aebisher and Dorota Bartusik-Aebisher
Medical College of The University of Rzeszów, Rzeszów, Poland

Part of the book: The Biochemical Guide to Enzymes

Abstract

Cancer is the leading cause of death in the world, with nearly 10 million people dying from cancer each year. As a result, for many years, doctors, pharmacists and biochemists from around the world have been working intensively on more and more effective therapies in the treatment of neoplastic diseases.

Keywords: pyruvate dehydrogenase, citric acid, Krebs cycle

References

Feng Y, Xiong Y, Qiao T, Li X, Jia L, Han Y. Lactate dehydrogenase A: A key player in
carcinogenesis and potential target in cancer therapy.
Cancer Med. 2018 Dec;7(12): 6124-6136.
Ferrarini MG, Nisimura LM, Girard RMBM, Alencar MB, Fragoso MSI, Araújo-Silva CA,
Veiga AA, Abud APR, Nardelli SC, Vommaro RC, Silber AM, France-Sagot M, Ávila
AR. Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as
Targets Worth Investigating for Effective Therapy of Toxoplasmosis.
mSphere. 2021 Jan 6;6(1):e01002-20.
Han Y, Sun W, Ren D, Zhang J, He Z, Fedorova J, Sun X, Han F, Li J. SIRT1 agonism
modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during
ischemia and reperfusion. Redox Biol. 2020 Jul;34:101538.
Palmieri EM, Gonzalez-Cotto M, Baseler WA, Davies LC, Ghesquière B, Maio N, Rice
CM, Rouault TA, Cassel T, Higashi RM, Lane AN, Fan TW, Wink DA, McVicar DW.
Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting
aconitase 2 and pyruvate dehydrogenase. Nat. Commun. 2020 Feb 4;11(1):698.
Stacpoole PW. Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate
Dehydrogenase Kinase (PDC/PDK) Axis in Cancer. J. Natl. Cancer Inst. 2017 Nov 1;109(11).