Łukasz Karaś, David Aebisher and Dorota Bartusik-Aebisher
Medical College of The University of Rzeszów, Rzeszów, Poland

Part of the book: The Biochemical Guide to Enzymes

Abstract

Acetaldehyde dehydrogenase is a group of enzymes found in the human body with a CAS number (9028-91-5). They constitute only the greater part of the enzymes from the dehydrogenase group, which are encoded by genes such as: ALDH1A1, ALDH2 and ALDH5. However, the presence of this enzyme depending on the race is different, and so people of the Northeast or people with blue eyes and blonde hair may show a mutation in the gene for this enzyme, which makes its effectiveness much more reduced.

Keywords: acetaldehyde dehydrogenase; enzyme; biochemistry

References

Pang J, Wang J, Zhang Y, Xu F, Chen Y. Targeting acetaldehyde dehydrogenase 2
(ALDH2) in heart failure-Recent insights and perspectives. Biochim. Biophys. Acta
Mol. Basis Dis. 2017 Aug;1863(8):1933-1941.
Wakabayashi Y, Tamura Y, Kouzaki K, Kikuchi N, Hiranuma K, Menuki K, Tajima T,
Yamanaka Y, Sakai A, Nakayama K I, Kawamoto T, Kitagawa K, Nakazato K.
Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen
species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 2020 Apr 1;318(4):R677-R690.
Acetaldehyde Dehydrogenase 17
Wang W, Wang C, Xu H, Gao Y. Aldehyde Dehydrogenase, Liver Disease and Cancer.
Int. J. Biol. Sci. 2020 Jan 22;16(6):921-934.
Wüthrich B. Allergic and intolerance reactions to wine.
Allergol. Select. 2018 Sep. 1;2(1): 80-88.
Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC,
Yin H. Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate
foam cell formation. J Clin Invest. 2019 Jan 2;129(1):252-267.