Maria Słobodzian, David Aebisher and Dorota Bartusik-Aebisher
Medical College of The University of Rzeszów, Poland

Part of the book: The Biochemical Guide to Enzymes

Abstract

Choline acetyltransferase (ChAT) is an enzyme produced in the central nervous system. This protein is synthesized in the body of cholinergic nerve cells, from where it is then transported to the axonal endings. Most probably, this transport takes place on a fast and slow road.

Keywords: choline acetyltransferase, renal terminals, enzymes, biochemistry

References

Abicht A, Müller JS, Lochmüller H. Congenital Myasthenic Syndromes Overview. 2003
May 9 [updated 2021 Dec 23]. In: Adam MP, Ardinger H H, Pagon R A, Wallace S
E, Bean L J H, Gripp K W, Mirzaa G M, Amemiya A, editors. GeneReviews®
[Internet]. Seattle (WA): University of Washington, Seattle; 1993–2021. PMID:
20301347.
Cox M A, Duncan G S, Lin G H Y, Steinberg B E, Yu L X, Brenner D, Buckler L N, Elia
A J, Wakeham A C, Nieman B, Dominguez-Brauer C, Elford A R, Gill K T, Kubli S
P, Haight J, Berger T, Ohashi P S, Tracey K J, Olofsson P S, Mak T W. Choline
acetyltransferase-expressing T cells are required to control chronic viral infection.
Science. 2019 Feb 8;363(6427):639-644.
Han B, Li X, Hao J. The cholinergic anti-inflammatory pathway: An innovative treatment
strategy for neurological diseases. Neurosci. Biobehav. Rev. 2017 Jun;77:358-368.
Toan N K, Tai N C, Kim S A, Ahn S G. Choline Acetyltransferase Induces the Functional
Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice. Int. J. Mol. Sci.
2021 Jan 2;22(1):404.
Zhang X, Lei B, Yuan Y, Zhang L, Hu L, Jin S, Kang B, Liao X, Sun W, Xu F, Zhong Y,
Hu J, Qi H. Brain control of humoral immune responses amenable to behavioural
modulation. Nature. 2020 May;581(7807):204-208.