Bartosz Ziobro, David Aebisher and Dorota Bartusik-Aebisher
Medical College of The University of Rzeszów, Poland

Part of the book: The Biochemical Guide to Enzymes

Abstract

Lactase (LPH-Lactase phlorozin hydrolase) is a protein with a molecular weight of about 160 kDa belonging to the 𝛽-galactosidase enzymes. LPH is found in the enterocyte cell membrane that forms the brush border of the small intestine. This is a characteristic feature of mammals, with the greatest amount of LPH being found in the middle of the small intestine. The gene encoding LPH is located on the long arm of the second chromosome (2q21).

Keywords: enzymes, lactase phlorozin hydrolase, biochemistry

References

Bayless T M, Brown E, Paige D M. Lactase Non-persistence and Lactose Intolerance. Curr.
Gastroenterol. Rep. 2017;19(5):23.
Forsgård R A. Lactose digestion in humans: intestinal lactase appears to be constitutive
whereas the colonic microbiome is adaptable. Am. J. Clin. Nutr. 2019;110(2):273-279.
Leis R, de Castro M J, de Lamas C, Picáns R, Couce M L. Effects of Prebiotic and Probiotic
Supplementation on Lactase Deficiency and Lactose Intolerance: A Systematic
Review of Controlled Trials. Nutrients. 2020;12(5):1487.
Ségurel L, Bon C. On the Evolution of Lactase Persistence in Humans. Annu. Rev.
Genomics Hum. Genet. 2017;18:297-319.
Stourman N, Moore J. Analysis of lactase in lactose intolerance supplements. Biochem.
Mol. Biol. Educ. 2018;46(6):652-662.