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Stina Simonsson and Dzeneta Vizlin-Hodzic
University of Gothenburg, Sweden
Series: Cell Biology Research Progress
BISAC: SCI017000
Somatic cells can be reprogrammed and serve as genetic material to generate a new individual, embryonic stem cells (ESCs), or a cell type of another kind than the original somatic cell. Production of ESCs from the patient’s own somatic cells is an attractive supply in medicine, in particular as individual human model system for drug-screening, drug-design or toxicology testing, but could also be used in regenerative medicine. This book provides some background, molecular mechanisms and breakthroughs underlying reprogramming of somatic cells and discusses some of the obstacles to overcome. (Imprint: Nova Biomedical)
Table of Contents
Abstract
Introduction
Human embryonic stem cells (hESCs)
Directed differentiation of hESCs
Gene Silencing during differentiation
Treatment of diseases with isogenic cells
Induced pluripotent stem cells (iPS cells)
Somatic Cell Nuclear Transfer (SNT)
History of Somatic Cell Nuclear Transfer (SCNT)
Final Remarks
Acknowledgments
References
Index
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