Oncology: The Promising Future of Biomarkers

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Anthony Furfari, M.D. (Editor)
Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Department of Bone and Soft Tissue Tumor, Liaoning Cancer Hospital and Institute, Dalian Medical University, Shenyang, Liaoning, China

George S. Charames (Editor)
Odette Cancer Centre, Sunnybrook Health Sciences Centre, CA

Rachel McDonald (Editor)
Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

Leigha Rowbottom (Editor)
Rapid Response Radiotherapy Program, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

Azar Azad (Editor)
Odette Cancer Centre, Sunnybrook Health Sciences Centre, CA

Stephanie Chan (Editor)
Odette Cancer Centre, Sunnybrook Health Sciences Centre, CA

Bo Angela Wan (Editor)
Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto ON, Canada

Ronald Chow (Editor)
Infinitas Research Group, London, Ontario, Canada

Carlo DeAngelis (Editor)
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada
Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Pearl Zaki (Editor)
Odette Cancer Centre, Sunnybrook Health Sciences Centre, CA

Edward Chow, Ph.D. (Editor)
Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Canada

Joav Merrick, M.D., MMedSci, DMSc, (Editor)
Division of Adolescent Medicine, KY Children’s Hospital, Department of Pediatrics, Lexington, Kentucky, USA
National Institute of Child Health and Human Development, Jerusalem, Israel
Division of Pediatrics, Hadassah Hebrew University Medical Centers, Mt Scopus Campus, Jerusalem, Israel
School of Public Health, Georgia State University, Atlanta, Georgia, USA

Series: Health and Human Development
BISAC: MED062000

Cancer is a term that describes a constellation of diseases that affect a large proportion of the global population. By 2020, it is estimated there will be 15 million new cancer cases worldwide and a corresponding 12 million cancer-related deaths. There are many efficacious treatments for cancer with both curative and palliative intents, which regardless of efficacy, can result in distressing symptoms including pain, fatigue, nausea, vomiting, and reduced function. Compounded with very similar symptoms from the disease itself, toxicities can ultimately lead to diminished quality of life (QOL).

In recent years, the use of biomarkers in cancer research and practice has become a widely discussed topic of exploration for researchers and clinicians alike. A biomarker is a biological property that can be measured and used as a tool in the prevention, diagnosis, and treatment of specific illnesses, including cancer. In this book, the authors synthesize existing biomarker research in the literature related to cancer and the potential effect it may have on future treatment, drug metabolism, symptom burden, radiation response, susceptibility to radiation related toxicities, and prognosis.
(Imprint: Nova Biomedical)

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Table of Contents

Table of Contents

Introduction

Chapter 1. Biomarkers and Oncology
Anthony Furfari, Leigha Rowbottom, Rachel McDonald, Carlo DeAngelis, Azar Azad, Stephanie Chan, Bo Angela Wan, Ronald Chow, Pearl Zaki, Edward Chow, George S. Charames, and Joav Merrick (Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada, and others)

Section One: Biomarkers

Chapter 2. Genetic Variants and Biological Markers of Cancer-Related Pain Sensitivity
Rachel McDonald, Adam Bobrowski, Matthew Choi, Stephanie Chan, Pearl Zaki, Bo Angela Wan, Anthony Furfari, Leigha Rowbottom, Henry Lam, Ronald Chow, George S. Charames, Azar Azad, Edward Chow, and Carlo DeAngelis (Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada, and others)

Chapter 3. Biomarkers, Cancer-Related Symptom Burden and Quality of Life
Leigha Rowbottom, Stephanie Chan, Bo Angela Wan, Pearl Zaki, Matthew Choi, Anthony Furfari, Rachel McDonald, Carlo DeAngelis, Azar Azad, Ronald Chow, Henry Lam, Edward Chow, and George S. Charames (Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada, and others)

Chapter 4. Biomarkers of Analgesics in the Management of Cancer Pain
Adam Bobrowski, Arnav Agarwal, Leigha Rowbottom, Rachel McDonald, Anthony Furfari, Stephanie Chan, Pearl Zaki, Bo Angela Wan, Henry Lam, Azar Azad, Ronald Chow, Edward Chow, George S. Charames, and Carlo DeAngelis (Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada, and others)

Chapter 5. Chemopreventative Capacity of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Adam Bobrowski, Arnav Agarwal, Anthony Furfari, Rachel McDonald, Leigha Rowbottom, Stephanie Chan, Pearl Zaki, Bo Angela Wan, Henry Lam, Azar Azad, Ronald Chow, George S. Charames, Edward Chow, and Carlo DeAngelis (Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada, and others)

Chapter 6. Biomarkers of Radiation Response
Matthew Choi, Leigha Rowbottom, Rachel McDonald, Anthony Furfari, Stephanie Chan, Bo Angela Wan, Pearl Zaki, Azar Azad, Ronald Chow, Carlo DeAngelis, Henry Lam, Edward Chow, and George S. Charames (Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada, and others)

Chapter 7. Biomarkers of Radiation Related Toxicities
Anthony Furfari, Stephanie Chan, Stephanie Cheon, Pearl Zaki, Bo Angela Wan, Leigha Rowbottom, Rachel McDonald, Azar Azad, Ronald Chow, Carlo DeAngelis, Michael Lam, Henry Lam, Edward Chow, and George S. Charames (Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada, and others)

Chapter 8. Common Inflammatory Biomarkers of Cancer Prognosis
Bo Angela Wan, Michael Lam, Anthony Furfari, Rachel McDonald, Leigha Rowbottom, Stephanie Chan, Pearl Zaki, Carlo DeAngelis, Ronald Chow, George S. Charames, Henry Lam, Edward Chow, and Azar Azad, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada, and others)

Chapter 9. Biological Biomarkers of Cancer Prognosis
Bo Angela Wan, Michael Lam, Anthony Furfari, Rachel McDonald, Leigha Rowbottom, Stephanie Chan, Pearl Zaki, Carlo DeAngelis, Ronald Chow, George S. Charames, Henry Lam, Edward Chow, and Azar Azad (Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada, and others)

Chapter 10. Genetic Biomarkers of Cancer Prognosis
Bo Angela Wan, Michael Lam, Anthony Furfari, Leigha Rowbottom, Rachel McDonald, Stephanie Chan, Pearl Zaki, Carlo DeAngelis, Azar Azad, Ronald Chow, Henry Lam, Edward Chow, and George S. Charames (Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada, and others)

Section Two: Future Aspects

Chapter 11. The Promising Future
Stephanie Chan, Bo Angela Wan, Pearl Zaki, Adam Bobrowski, Matthew Choi, Carlo DeAngelis, Azar Azad, Rachel McDonald, Leigha Rowbottom, Anthony Furfari, Ronald Chow, Edward Chow, and George S. Charames (Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada, and others)

Section Three: Acknowledgements

Chapter 12. About the Editors

Chapter 13. About the Rapid Response Radiotherapy Program at the Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Canada

Chapter 14. About the National Institute of Child Health and Human Development, Israel

Chapter 15. About the Book Series “Health and Human Development”

Section Four: Index

Index

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