Table of Contents

Table of Contents

Foreword
(Pierre Daloze, University of Montreal, Canada)

Preface
(Huifang Chen and Shiguang Qian, University of Montreal, Canada, and Cleveland Clinic, USA)

Part I: Immunologic Basis

Chapter 1
Immunology Principles in Organ Transplantation
(Daniel Joyce, Cleveland Clinic, USA)

Chapter 2
Cellular and Humoral Responses in Organ Transplantation
(Wenhao Chen, Cornell University, USA)

Chapter 3
Historical Remarks of Immunosuppressive Therapy in Organ Transplantation
(Huifang Chen, Anlun Ma, and Pierre Daloze, University of Montreal, Canada)

Chapter 4
Animal Models in Immunosuppression
(James McDaid, Dept of Transplant Surgery, City Hospital, Belfast, UK)

Chapter 5
Ethical Issues of Immunosuppressive Drugs Use in Organ Transplantation
(Kupa Bilolo and Edna Montero, University of Montreal, Canada, and University of Sao Paulo Medical School, Brazil)

Part II: Therapeutic Agents

Chapter 6
Glucocorticoids
(Yanxin Hu, University of Montreal, Canada)

Chapter 7
Small Molecules in Solid Organ Transplantation with Cytostatic Antiproliferative Effects
(René H. Tolba, Institute Fur Versuchstierkunde, Universitsklinikum Aachen, Germany)

Chapter 8
Calcineurin Inhibitors
(Junzheng Peng and Edna Montero, CRCHUM, University of Montreal, Canada, and University of Sao Paulo Medical School, Brazil)

Chapter 9
Inhibitors of Mammalian Target of Rapamycin
(Kupa Bilolo and Huifang Chen, University of Montreal, Canada)

Chapter 10
Immunomodulation Therapy by the Control of Immune Cell Trafficking
(Takashi Murakami and Eiji Kobayashi, Laboratory of Tumor Biology, Takasaki University of Health and Welfare, Japan, and Department of Organ Fabrication, Keio University, Japan)

Chapter 11
Protein Kinase C Inhibitors
(Guang Yu, Liaoning Medical University, China)

Chapter 12
Agents Targeting JAK3 in Organ Transplantation
(Hao Dun, University of Montreal, Canada)

Chapter 13
Costimulation Blockers
(Lijun Song, University of Montreal, Canada)

Chapter 14
Adhesion Molecules: Therapeutic Targets for Allograft Rejection and Ischemia-Reperfusion Injury
(René H. Tolba, Institute Fur Versuchstierkunde, Universitsklinikum Aachen, Germany)

Chapter 15
Agents Targeting B-cells and the Humoral Responses
(Mihai Oltean, the Transplantation Institute, Sahlgrenska University Hospital, Sweden)

Chapter 16
Agents Targeting Plasma Cells
(Paulo N. Martins, University of Massachusetts, USA)

Chapter 17
Immunosuppressive Antibodies
(Guang Yu, and Xuemin Xu, Liaoning University, China)

Chapter 18
Complement Inhibitors
(Paulo N. Martins, University of Massachusetts, USA)

Chapter 19
Agents Targeting Ischemia-Reperfusion Injury
(Norbert Nemeth, Balazs Nemes, University of Debrecen, Hungary)

Part III: Cell Therapy in Induction of Transplant Tolerance

Chapter 20
Cellular Therapies in Induction of Transplantation Tolerance
(Sumantha Bhatt and Shiguang Qian, Cleveland Clinic, USA)

Chapter 21
Stem Cell-Derived Immunosuppressive Cells Therapy in Organ Transplantation
(Xiaokang Li, Chief, Division of Transplantation Immunology, National Research Institute for Child Health and Development, Okura, Setagaya-Ku, Tokyo, Japan)

Chapter 22
Does MSCs have a place in Transplantation?
(Feng Lin, Department of Immunology, Lerner Research Institute, Cleveland Clinic, USA)

Chapter 23
Donor Hematopoietic Stem Cells
(Joel T. Adler, Beth Amundsen, Tatsuo Kawai, Massachusetts General Hospital, USA)

Index