Basic Biology and Current Understanding of Skeletal Muscle

$205.00

Kunihiro Sakuma (Editor)
Toyohashi University of Technology, Tenpaku-cho, Toyohashi, Japan

Series: Muscular System – Anatomy, Functions and Injuries, Human Anatomy and Physiology
BISAC: MED005000

Skeletal muscle is a highly plastic tissue that constitutes approximately thirty percent of total body mass and adapts rapidly to changing functional demands. Skeletal muscle is not only the generator of force production, but also plays a crucial role in whole body metabolism and energy consumption. In this book, leading experts in the area of exercise biochemistry and molecular biology in skeletal muscle provide an up-to-date view of the molecular basis of various adaptations of skeletal muscle, with emphasis on new biological concepts (muscle stem cells, muscle steroidogenesis, etc.).

This book deals with the recent intriguing role of heat shock protein (HSP), AMPK and reactive oxygen species (ROS) for muscle morphology, function and metabolism. Discussed also is the molecular mechanism for protein metabolism and therapeutic application for sarcopenia. The deeper understanding of the signal transduction and modification in skeletal muscle will develop new therapeutic strategies for preventing physical disability and increased risk of morbidity/mortality due to the loss of muscle mass. (Imprint: Nova Biomedical )

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Table of Contents

Table of Contents

Chapter 1. Stem Cell Hierarchies in Muscle Satellite Cells
(Yusuke Ono, Department of Stem Cell Biology, Life Science and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, Japan)

Chapter 2. Cellular Mechanisms Regulating Protein Metabolism in Skeletal Muscle Cells: Age-Associated Alteration of Intracellular Signaling Governing Protein Synthesis and Degradation
(Mitsunori Miyazaki, Department of Physical Therapy, School of Rehabilitation Sciences, Health Sciences University of Hokkaido, Japan)

Chapter 3. Biological Actions of Insulin-Like Growth Factor-I (IGF-I) Isoforms and IGF Binding Proteins in Skeletal Muscle
(Akihiko Yamaguchi, Kunihiro Sakuma and Isao Morita, Department of Integrated Human Sciences, School of Dentistry, Health Sciences University of Hokkaido, Japan, and others)

Chapter 4. An Overview of the Therapeutic Strategies for Preventing Sarcopenia
(Kunihiro Sakuma and Akihiko Yamaguchi, Research Center for Physical Fitness, Sports and Health, Toyohashi University of Technology, Japan, and others)

Chapter 5. Oxidative Stress-Induced Signal Transduction in Skeletal Muscle
(Wataru Aoi, Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Japan)

Chapter 6. The Functional Roles of Heat Shock Proteins in Skeletal Muscle
(Tomonori Ogata, Faculty of Human Environmental Studies, Hiroshima Shudo University, Japan)

Chapter 7. Mechanical Stress and Myofibrillar Structure
(Fuminori Kawano, Department of Health and Sport Sciences, Graduate School of Medicine, Osaka University, Japan)

Chapter 8. AMPK: Molecular Mechanisms of Metabolic Adaptations in Skeletal Muscle
(Masataka Suwa, Faculty of Life Design, Tohoku Institute of Technology, Japan)

Chapter 9. A Role for Mitochondria as a Potential Regulator of Myogenesis
(Akira Wagatsuma, Graduate School of Information Science and Technology, the University of Tokyo, Japan)

Chapter 10. Skeletal Muscle Adaptation and Local Steroidogenesis
(Katsuji Aizawa, Senshu University Institute of Sport, Kanagawa, Japan)

Index

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