https://novapublishers.com Publisher of Books and Journals in Medicine and Health, Science and Technology and Social Sciences Fri, 13 Jan 2023 16:38:26 +0000 en-US hourly 1 https://wordpress.org/?v=6.1.1 https://novapublishers.com/wp-content/uploads/2018/08/cropped-nova-favicon-32x32.jpg https://novapublishers.com 32 32 https://novapublishers.com/shop/dementia-diabetes-and-hypertension-is-there-a-unified-theory-through-a-dysregulation-of-the-ca2-homeostasis/ Tue, 09 Feb 2021 16:16:07 +0000 https://novapublishers.com/?post_type=product&p=91318 Series: Research Progress in Alzheimer’s Disease and Dementia BISAC: MED000000 Dementia, diabetes, and hypertension are considered huge medical problems around the world, costing many millions of dollars to the medical health systems. Curiously, hypertension has been clinically linked with a higher risk for decline of cognition, as shown in dementia patients. In addition, there is a clear clinical association between hypertension and diabetes, reflecting substantial similarities in their etiology. In fact, consistent data support that patients diagnosed with diabetes have shown an increased risk of presenting cognitive dysfunctions, clinical signs of dementia. Considering the cumulative knowledge from the scientific literature, we can now link Ca2+ signals dysregulations as an upstream issue for hypertension, diabetes and other inflammatory processes, and dementia. Regarding therapeutics, hypertensive patients have been classically treated with Ca2+ channel blockers (CCBs), medicines whose mechanism of action consists in reducing the influx of Ca2+ into the cells. Intriguingly, many clinical reports have been demonstrating off-label effects for CCBs. In hypertensive patients treated with CCBs, it can be observed a lower incidence of dementia such as Alzheimer´s disease. The possible mechanism of action could be attributed to a restoration of the Ca2+ homeostasis. In addition, in hypertensive patients treated with CCBs, it can be also observed an improvement of diabetes status such as glycemic control. A possible mechanism of action could be due to a restoration of insulin secretion, then achieving glycemic control, and a reduction of the pancreatic β-cell apoptosis. Thus, this book puts together fundamental concepts, and current therapies to treat dementia, hypertension, and diabetes, including novel therapeutics coming from the pharmacological manipulation of Ca2+/cAMP signalling. Finally, this book compiles more than 300 references from the scientific literature, including data of high evidence such as meta-analysis and systematic reviews, and discusses pharmaceuticals already approved and clinically safe, e.g., CCBs, then allowing sustained increments in the life quality of age-related patients.]]> https://novapublishers.com/shop/international-approaches-to-alzheimers-disease-and-dementia/ Wed, 01 May 2019 12:41:26 +0000 https://novapublishers.com/?post_type=product&p=46247 Lorraine N. Salomon (Editor) Series: Geriatrics, Gerontology and Elderly Issues BISAC: MED056000 The healthy human brain contains tens of billions of neurons, specialized cells that process and transmit information via electrical and chemical signals. While the brain may shrink to some degree in healthy aging, it does not lose neurons in large numbers. In Alzheimer’s disease, however, damage is widespread as many neurons stop functioning, lose connections with other neurons, and die. Alzheimer’s disrupts processes vital to neurons and their networks, including communication, metabolism, and repair. At first, the disease typically destroys neurons and their connections in parts of the brain involved in memory, including the entorhinal cortex and the hippocampus. It later affects areas in the cerebral cortex responsible for language, reasoning, and social behavior. Eventually, many other areas of the brain are damaged, and a person with Alzheimer’s becomes helpless and unresponsive to the outside world. This book provides an international approach to dealing with Alzheimer's disease and dementia, as well as discusses the effect this disease has on the brain and its function. (Imprint: Nova Biomedical )]]> https://novapublishers.com/shop/national-plan-to-address-alzheimers-disease-goals-and-progress/ Wed, 01 May 2019 12:32:50 +0000 https://novapublishers.com/?post_type=product&p=46232 Melanie Haggard (Editor) Series: Geriatrics, Gerontology and Elderly Issues BISAC: HEA039140 For millions of Americans, the heartbreak of watching a loved one struggle with Alzheimer's disease is a pain they know all too well. Alzheimer's disease burdens an increasing number of our Nation's elders and their families, and it is essential that we confront the challenge it poses to our public health. In 2011, President Barack Obama signed into law the National Alzheimer’s Project Act (NAPA), requiring the Secretary of the U.S. Department of Health and Human Services (HHS) to establish the National Alzheimer’s Project to create and maintain an integrated national plan to overcome Alzheimer’s disease; coordinate Alzheimer’s disease research and services across all federal agencies; accelerate the development of treatments that would prevent, halt, or reverse the course of Alzheimer’s disease; improve early diagnosis and coordination of care and treatment of Alzheimer’s disease; improve outcomes for ethnic and racial minority populations that are at higher risk for Alzheimer’s disease and to coordinate with international bodies to fight Alzheimer’s globally. This book addresses each of these points and provides further insight on the national plan to address this disease. (Imprint: Novinka )]]> https://novapublishers.com/shop/alzheimers-disease-a-caregivers-guide/ Mon, 22 Apr 2019 16:54:02 +0000 https://novapublishers.com/?post_type=product&p=43518 Diana B. Watkins (Editor) Series: Aging Issues, Health and Financial Alternatives BISAC: MED011000 Alzheimer’s disease is an illness of the brain. It causes large numbers of nerve cells in the brain to die. This affects a person’s ability to remember things and think clearly. People with AD become forgetful and easily confused. They may have a hard time concentrating and behave in odd ways. These problems get worse as the illness gets worse, making it more difficult for caregivers. Caring for a person with Alzheimer’s disease is a challenge that calls upon the patience, creativity, knowledge, and skills of each caregiver. This book is for those who provide in-home care for people with Alzheimer’s disease or related disorders. The goal is to improve home safety by identifying potential problems in the home and offering possible solutions to help prevent accidents. (Imprint: Nova Biomedical )]]> https://novapublishers.com/shop/when-its-not-alzheimers-types-treatment-and-resources-for-other-forms-of-dementia/ Mon, 22 Apr 2019 15:54:43 +0000 https://novapublishers.com/?post_type=product&p=43455 Kristeen V. Wolf (Editor) Series: Aging Issues, Health and Financial Alternatives BISAC: HEA039110 A diagnosis of dementia can be frightening for those affected by the syndrome, their family members, and caretakers. Alzheimer’s disease (AD) is the most common form of dementia in those over the age of 65. As many as 5 million Americans age 65 and older may have AD, and that number is expected to double for every 5-year interval beyond age 65. But Alzheimer’s is only one of many dementia disorders; another 1.8 million people in the U.S. have some other form of dementia. Among all people with dementia, many are believed to have a mixed type of dementia that can involve more than one of the disorders. This book provides a general overview of various types of dementia, describes how the disorders are diagnosed and treated, and offers highlights of research that is supported by the National Institute of Neurological Disorders and Stroke and the National Institute on Aging, both a part of the National Institutes of Health (NIH). (Imprint: Nova Biomedical )]]> https://novapublishers.com/shop/brain-ischemia-alzheimers-disease-mechanisms/ Mon, 07 Jan 2019 12:55:08 +0000 https://novapublishers.com/?post_type=product&p=24882 Series: Neuroscience Research Progress BISAC: MED056000 This new book presents a summary of Alzheimer’s disease-related ischemic protein changes and gene expression as risk factors for the late-onset of sporadic Alzheimer’s disease, and their role in Alzheimer’s disease ischemic etiology. Ischemic brain changes were noted in the staining of different parts of an amyloid protein precursor, presenilin 1 and 2, tau protein, alfa-synuclein, and apolipoproteins A1, E and J. Current advances in understanding the ischemic etiology of Alzheimer’s disease has revealed dysregulation of Alzheimer’s disease-associated genes including presenilin 1 and 2, β-secretase, amyloid protein precursor, apoptosis, autophagy, mitophagy, and tau protein. This book presents the relationship between these genes, dysregulated by cerebral ischemia, and the cellular and tissue neuropathology characteristic of Alzheimer's disease. This book draws attention to the latest research confirming the theory that Alzheimer's disease-related proteins and genes play an important role in ischemic brain damage, and ischemia is an essential and leading supplier for the onset and progression of sporadic Alzheimer's disease. The above data comes from the latest research from leading and renowned scientists around the world, who present important information on the understanding of the ischemic etiology of Alzheimer's disease. In the future, it is likely that the manipulation of ischemia and ischemia-activated Alzheimer's disease-associated genes and their proteins will give new hope for the development of causal therapies urgently needed to prevent or treat neurodegenerative diseases such as Alzheimer's disease. An innovative/modern approach to the etiology of Alzheimer's disease in the chapter XII "Ischemic etiology of Alzheimer's disease" will give the reader a glimpse of what is on the horizon. (Imprint: Nova Medicine and Health)]]> https://novapublishers.com/shop/healing-the-mind-alzheimers-disease-thinking-patents-1983-2007/ Tue, 27 Nov 2018 18:11:04 +0000 https://novapublishers.com/?post_type=product&p=18863 Series: Neuroscience Research Progress BISAC: MED057000 The brain is a masterpiece that defines your uniqueness. As you age, though, your brain may be susceptible to a terrible disease. Alzheimer’s disease is the most common cause of dementia among older adults. It is considered an irreversible, progressive brain disorder that slowly erases memories and thinking, and eventually eliminates the ability to carry out the simplest of tasks. Alzheimer’s disease may rank third, just behind heart disease and cancer, as the leading cause of death for elderly people. Medical science continues to make progress in the search for therapeutic interventions and a cure. Since 1983, hundreds of Alzheimer’s-related patents have been granted by the United States Patent and Trademark Office in an effort to eradicate this deadly disease. To better understand these inventions, Michael J. Dochniak has written this book to provide an easy-to-read, brief summary of such patents. Within the summaries are inventor profiles and news articles that are insightful and relevant. Impactful inventors include a Nobel laureate, a soldier and an ex-convict. Pioneering inventors include George Glenner, Barbara Cordell, Birinder Boveja, Joseph Buxbaum, Dale Schenk and Vivian Hook. At the beginning of several chapters, you will experience a personal story about Alzheimer’s disease. Most importantly, the book this novel is about keeping your brain healthy as you age. (Imprint: Nova Biomedical)]]> https://novapublishers.com/shop/research-progress-in-alzheimers-disease-and-dementia-volume-6/ Mon, 19 Nov 2018 13:23:26 +0000 https://novapublishers.com/?post_type=product&p=16837 Miao-Kun Sun (Editor) Blanchette Rockefeller Neurosciences Institute, Rockville, MD, USA Series: Research Progress in Alzheimer's Disease and Dementia BISAC: BUS016000 Memory impairment due to aging and various memory disorders represent a great medical challenge to our society. Since the publication of the fifth volume of this collection, the rapid progress in the research fields of Alzheimer’s disease (AD) and other types of dementias continues through the intense efforts of research scientists worldwide. This sixth volume contains eight chapters, bringing together a presentation of scientific frontiers in current AD/dementia research. The topics include a discussion on impairments in dementias, memory binding in AD, therapeutic targeting of BACE1 and neprilysin, Tau Immunotherapy, targeting 5-lipoxygenase targets for tauopathy, potential therapeutics for frontotemporal dementia, potential therapeutics for Down’s syndrome, and cognitive rehabilitation in multiple sclerosis. Research advances in these areas are presented and discussed in great detail in the chapters. The book will be highly valuable to students and scientists worldwide who are interested in the scientific research and progress in AD and memory disorders. (Imprint: Nova Biomedical)]]> https://novapublishers.com/shop/alzheimers-disease-awareness-among-young-adults/ Thu, 01 Nov 2018 17:21:40 +0000 https://novapublishers.com/?post_type=product&p=13662 Ronald Chow (Editor) Infinitas Research Group, London, Ontario, Canada Drew Hollenberg (Editor) Infinitas Research Group, London, Ontario, Canada Michael Borean (Editor) Infinitas Research Group, London, Ontario, Canada Joav Merrick, M.D., MMedSci, DMSc, (Editor) Division of Adolescent Medicine, KY Children's Hospital, Department of Pediatrics, Lexington, Kentucky, USA National Institute of Child Health and Human Development, Jerusalem, Israel Division of Pediatrics, Hadassah Hebrew University Medical Centers, Mt Scopus Campus, Jerusalem, Israel School of Public Health, Georgia State University, Atlanta, Georgia, USA Series: Public Health: Practices, Methods and Policies BISAC: HEA039140 Alzheimer’s disease will become more prevalent in the upcoming decades. With no cure on the horizon, it is important that close relatives and family members of affected patients become knowledgeable about the disease; they can be more conscientious caregivers and improve quality of life. Awareness and knowledge of the disease are especially important for the young adult population, as they will be heavily relied upon in the future to care for those with the disease. In this book, we present studies that looked into the awareness level of young adults by geographical location, age, sex, and familial ties to the disease. (Imprint: Nova)]]>