Diabetes and Diabetic Complications: Current Status and Future Perspectives

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Series: Endocrinology Research and Clinical Developments

BISAC: MED027000

Diabetes mellitus is one of the major causes of morbidity and mortality in the modern world. Persistent hyperglycaemia is responsible for several complications of diabetes, such as diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, diabetic cardiomyopathy, diabetic autonomic neuropathy, diabetic ketoacidosis, diabetic foot ulcer, gestational diabetes, and diabetic mastopathy. With the advancement of technology, several new drugs have been developed for treatment of diabetes and diabetic complications. Moreover, alternative and complementary medicines have also been employed to manage diabetes and its associated complications. Despite the availability of a plethora of therapeutic agents, the management of diabetes and diabetic complications is an uphill battle associated with several limitations. Various leading research groups across the world are investing billions of dollars to develop impeccable solutions for the treatment of diabetes and diabetic complications.

This book focuses on the understanding of recent advancements in the pathogenesis of diabetes and diabetic complications, the molecular basis of the disease and recent advancements in diabetic treatment. The chapters are specifically dedicated to different complications associated with diabetes. Moreover, recent advances in treatments and medications in clinical trials for these complications are explained. Some chapters are dedicated to the use of herbal medicines, alternative and complementary therapy and personalized medicines. Furthermore, the role of epigenetics in diabetic complications is described, as well as the role of antidiabetic drugs and their interactions.

Due to its widespread prevalence, diabetes is presently considered a pandemic. This book provides contemporary information to researchers and health care practitioners about diabetes and diabetic complications, which may pave the way for designing new strategies to manage diabetes and diabetic complications. Moreover, the insights on alternative and complementary medicines will help in providing a background for inclusion of these medicines as an important therapeutic option for treatment of diabetes.

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Table of Contents

Preface

Chapter 1. Comprehending Type-I Diabetes Mellitus
(Kajal Bagri, Vivek Sharma and Rahul Deshmukh, PhD – Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India, et al.)

Chapter 2. Comprehending Type-II Diabetes Mellitus
(Gurfateh Singh, PhD, Monisha Bansal and Ramica Sharma – University School of Pharmaceutical Sciences, Rayat-Bahra University, Mohali, Punjab, India, et al.)

Chapter 3. Diabetes and Diabetic Complications: Current Status and Future Prospective
(Rohit, Jagdish Chandra and Shamsher Singh Bajwa, PhD – Department of Pharmacy Practice, ISF College of Pharmacy, Moga, Punjab, India, et al.)

Chapter 4. Molecular Basis of Diabetic Nephropathy
(S. M. Firdous, Soumyadeep Ghosh, Priyodarshini Nath and Heena Khan – Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences, Banitabla, Uluberia, Howrah, West Bengal, India, et al.)

Chapter 5. Diabetic Neuropathy: Pathogenesis and Therapeutic Management
(Simerjeet Kaur Chahal, PhD, Rupinder Kaur Sodhi, Jitender Madan and Yuvraj Singh – Department of Pharmacology, Chandigarh College of Pharmacy, Mohali Punjab, India, et al.)

Chapter 6. Diabetic Retinopathy: Pathogenesis and Therapeutic Management
(S. M. Firdous, PhD, Piyali Dhang, Akash Koley and Heena Khan – Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences, Howrah, West Bengal, India, et al.)

Chapter 7. Diabetic Cardiomyopathy: Pathophysiological Mechanisms and Potential Target Sites
(Tajpreet Kaur, Ravi Kumar Dhawan, Ashwani Kumar Sharma and Amrit Pal Singh – Department of Pharmacology, Khalsa College of Pharmacy, Amritsar, India, et al.)

Chapter 8. Diabetic Mastopathy: Pathogenesis and Therapeutic Management
(Kamalpreet Mehra, Devesh Aggarwal and Gaaminepreet Singh – Maharishi Markandeswar College of Pharmacy, Mullana, Ambala, India, et al.)

Chapter 9. Diabetic Foot Ulcer: Pathogenies and Treatment Strategies
(Lakshita Bhargava, Violina Kakoty, K. C. Sarathlal, Sunil Kumar Dubey and Rajeev Taliyan, PhD – Neuropsychopharmacology Division, Department of Pharmacy, Birla Institute of Technology and Science-Pilani, Pilani, India)

Chapter 10. Diabetic Ketoacidosis: Pathogenesis and Treatment
(Parminder Nain, PhD and Jaspreet Kaur – Department of Pharmacy Practice, M. M. Collge of Pharmacy, Maharishi Markandeshwar (Deemed to be University) Mullana-Ambala (Haryana), India)

Chapter 11. Diabetic Autonomic Neuropathy: Pathogenesis and Treatment
(Manish Kumar, PhD, Amritpal Singh, Nikhil Garg and Suman Bainshab – Swift School of Pharmacy, Rajpura, Punjab, India, et al.)

Chapter 12. The Role of Epigenetic in Complications of Diabetes-Mellitus
(Ranjana Bhandari, Garima Khanna and Anurag Kuhad, PhD – Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC-Centre of Advanced Study, Panjab University, Chandigarh, India)

Chapter 13. Role of Oxidative Stress and Inflammation in Complications of Diabetes
(Kuldeep Kumar, Sonal, Nirmal Singh, PhD, Dhandeep Singh, Amteshwar S. Jaggi, Jashanjot Singh,Pooja Rawat and Prabhjot Kaur – Department of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala, Patiala, Punjab, India)

Chapter 14. Diabetes in Pregnancy – Gestational Diabetes Mellitus
(Nidhi Garg, Nincy Philip, Ravinder Singh, Kiranjeet Kaur, Monika Rani, Nikhil Garg, Saurabh Gupta, Sonia Dhiman, Shaima K.A – Chitkara college of Pharmacy, Chitkara University, Punjab, India, et al.)

Chapter 15. Novel Pharmacological Approaches for Diabetic Complications
(Anchal Arora, Uma Shanker Navik, Aiswarya Jaiswal, Prabhsharan Kaur and Puneet Kumar – Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India, et al.)

Chapter 16. Personalized Medicine for Management of Diabetic Complications
(Shareen Singh, Thakur Gurjeet Singh, PhD, Ashish Kumar Rehni, Kunal Dhiman and Shamsher Singh – Chitkara College of Pharmacy, Chitkara University, Punjab, India, et al.)

Chapter 17. Pharmacokinetics of Antidiabetic Drugs and Their Interactions
(Rakesh Gollen, Salvatore Rizzo and Sumanta Kumar Goswami – Director, Pharmacokinetics, Synteract Inc., NC, US, et al.)

Chapter 18. Diabetic Complications and Non-Conventional Therapies
(Amit Banerjee, Tarun Chhabra, Shareen Singh, A. Rohini and Thakur Gurjeet Singh Jhajj, PhD – Chitkara College of Pharmacy, Chitkara University, Punjab, India, et al.)

Chapter 19. Drugs in Clinical Research for Management of Diabetic Complications
(Amarjot Kaur, Komal Thapa, Nikhil Garg, Anjali Gupta, Thakur Gurjeet Singh and Govind Arora – Chitkara College of Pharmacy, Chitkara University, Punjab, India)

Chapter 20. Herbal Approach in Management of Diabetes and Its Complications
(Nikhil Garg, Ashi Mannan, Shareen Singh, Thakur Gurjeet Singh, PhD and Randhir Singh – Chitkara College of Pharmacy, Chitkara University, Punjab, India, et al.)

Chapter 21. Quality of Life (QoL) in Diabetes Mellitus
(Ravinder Singh, Nidhi Garg, Pratima Syal, Stakshi Sood, Monika Rani, Kiranjeet Kaur, Manjinder Singh and Balraj Saini – Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India)

Index

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